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CRSP·CRISPR Therapeutics AG

$52.01
-0.95 (-1.79%)
High
$53.60
Open
$52.57
Market Cap
5.12B
52W High
$78.48
Low
$51.70
P. Close
$52.01
P/E
-
52W Low
$44.00
Fwd P/E
-15.14
DailyIQ Est.
$103.68
Inst. Ownership
32.2%
Short Interest
19.08%
Days to Cover
10.7
Technical Score (1D)
41
SELL
News Sentiment
55
BULLISH
CRISPR Therapeutics’ shares slipped 2.4 % in the last 24 hours, a move that mirrors the broader market dip while the biomedical sector gained 2.9 %. The decline is largely attributed to Zacks’ focus on earnings estimate revisions, suggesting that any near‑term upgrade or downgrade could sway the stock’s trajectory. In the next 1–10 trading days, traders should watch for the next round of analyst estimates and any corporate announcements that could shift valuation expectations. Fifteen hours ago, CEO Sam Kulkarni highlighted a sustained commercial push for the flagship gene therapy CASGEVY, noting that several pipeline programs are slated to deliver data by the end of 2026. The CEO’s emphasis on expanding CASGEVY adoption signals a potential uptick in sales once the FDA expands its indication to patients aged two and older, a development that could accelerate revenue growth. The company also announced that Phase 1b data for CTX310, Phase 2 results for CTX611, and updates from its zugo‑cel autoimmune program are expected by year‑end, providing multiple catalysts that could lift the stock if the data are positive. The same 15‑hour update also mentioned that additional clinical data on in‑vivo gene‑editing platforms will be released through 2027, reinforcing long‑term pipeline strength. This breadth of upcoming data releases means that the next few weeks could see a series of incremental valuation adjustments as each milestone is reported. At 22 hours ago, CRISPR presented at the Morgan Stanley 24th Annual Global Healthcare Conference, reiterating its current pipeline progress and strategic priorities without disclosing new financial guidance. The presentation underscored that the company’s focus remains on ongoing clinical trials and milestone dates, so any deviation from the projected timelines could impact investor sentiment. In summary, the immediate catalyst is the earnings estimate focus, while the longer‑term drivers are the CASGEVY FDA expansion and the series of year‑end clinical data releases. Traders should monitor analyst revisions, FDA updates on CASGEVY, and the release of Phase 1b and Phase 2 data for CTX310 and CTX611, as each could materially influence the stock’s valuation over the next ten trading days.
Earnings Summary
CRISPR Therapeutics AG is a gene‑editing biotechnology company focused on developing CRISPR/Cas9‑based therapies for serious diseases, with a flagship product, CASGEVY, targeting hemoglobinopathies. The company operates in the high‑growth biotech sector, collaborating with Vertex, Nkarta, and Capsida to advance its pipeline across oncology, autoimmune, and metabolic indications. In Q4 2024, the company posted a loss of $0.44 per share versus an estimate of –$1.19, while revenue of $35.7 million was reported; in Q1 2025 the loss widened to $1.58 per share against an estimate of –$1.28, with revenue falling sharply to $0.865 million. Q2 2025 saw a modest improvement, with a loss of $1.29 per share versus an estimate of –$1.40 and revenue of $0.892 million, and Q3 2025 continued a similar trend with a loss of $1.17 per share versus –$1.29 and revenue of $0.889 million. The company’s revenue has been volatile, with a significant spike in Q4 2024 followed by a steep decline in the first half of 2025, while EPS losses have narrowed slightly in Q2 and Q3. Historically, CRISPR has shown a YoY revenue growth trajectory in quarters where clinical milestones were announced, but EPS has consistently remained negative, reflecting heavy R&D spend. Recent news highlights a market‑outperform upgrade from Citigroup, citing improved profitability in Q2 and a narrowed loss margin, and an upward price target lift to $88, suggesting renewed investor confidence tied to pipeline progress and potential regulatory approvals. Investors should watch the next earnings release for guidance on commercialization timelines, especially regarding CASGEVY and upcoming siRNA data, as these milestones will likely influence revenue projections and margin expectations. The company’s ability to convert clinical success into cash flow will be a key metric for the next quarter.

EPS

EstBeatMiss
$-1.75$-1.38$-1.01$-0.64$-0.27Q4'24Q1'25Q2'25Q3'25Q4'25
QtrEstActual+/−
Q4'25$-1.05 - -
Q3'25$-1.29$-1.17+9.2%
Q2'25$-1.40$-1.29+7.8%
Q1'25$-1.28$-1.58-23.8%
Q4'24$-1.19$-0.44+62.9%

Revenue

EstBeatMiss
$-4M$7M$18M$30M$41MQ4'24Q1'25Q2'25Q3'25Q4'25
QtrEstActual+/−
Q4'25$10M - -
Q3'25 - $889,000 -
Q2'25 - $892,000 -
Q1'25 - $865,000 -
Q4'24 - $36M -

Market Data

CRSP Stock Snapshot

HOLD41/100
$52.01$0.95 (1.8%)
Market cap
5.12B
Day range
$51.70 – $53.60
News sentiment
55/100 · Neutral
Analyst target
$87.56 (+68.4%)
Consensus
Buy · 30 analysts
52-week range+18.2% off low · -33.7% from high
$44.00$78.48
Price $52.01 DailyIQ Est. $103.68

Neither side has the upper hand on CRSP right now, and the indicator set reflects that. Company-specific news dominates here; sector-level flows matter less than for larger names.

Behaviour On Record

What CRSP's own history says about today's numbers

Realized volatility (21d)
56.7% 44th pct
Below its peak
-75.3%
vs 200-day average
-1.3%
Up days (1y)
46%

CRISPR Therapeutics AG is currently running 56.7% annualised volatility over the last 21 sessions. Measured against CRSP's own 10 years of daily returns rather than a market-wide average, that is the 44th percentile close to its own typical level, against a typical reading of 59.3%. The distinction matters because a number that looks calm for one stock is turbulent for another, and the absolute figure on its own tells you neither.

CRSP is trading -75.3% below its running peak. Across 9 full years on file, its median worst-drawdown-in-a-year was -43.6%, and the deepest was -67.2% in 2021. The current drawdown is already deeper than this stock's typical annual low point, which puts it in the part of its range where past recoveries began — and where past declines also continued.

Price sits -1.3% from its 200-day moving average. Against every other day in its history, that gap ranks at the 48th percentile close to the gap it normally carries. Over the past year CRSP closed higher on 46% of sessions, and it is currently 1 session into a rising streak.

On September specifically: over 9 years of records, CRSP finished the month higher 2 of 9 times, with a median return of -9.7% and an average of -5.3%. Its strongest month historically has been November at +15.1% on average, its weakest March at -9.9%. Seasonality is a weak signal on its own — a decade is a small sample and regimes change — but it is a real distribution rather than a rule of thumb.

Overnight risk is measurable too: CRSP has opened more than 2% away from the prior close in 361 of 2,487 sessions (14.5% of the time), with the largest gaps running +13.9% and -10.1%. For anyone holding through an event, that rate is a better guide to overnight exposure than the intraday range.

All figures computed from 2,488 daily closes between 2016-10-19 and 2026-09-14, split-adjusted, recomputed daily. Percentiles are against CRSP's own 10-year history, not a peer group or index.

Sector Rotation

Is money rotating into or out of CRSP's sector?

CRISPR Therapeutics AG sits in the Health Care sector, currently ranked 3rd of 11 GICS sectors by relative-strength rotation score (leading). Within its narrower Biotechnology industry group, CRSP ranks 4th of 15 tracked industries, lagging.

Sector rank
#3 of 11
Sector state
Leading
Sector rotation score
80
Industry rank
#4 of 15

Options Market

What is the options market pricing for CRSP?

CallsPuts

For CRISPR Therapeutics AG's nearest expiry (2026-09-18, 3 days out), open interest is roughly balanced between puts and calls (put/call ratio of 0.93), with at-the-money implied volatility around 76.6%. The options market is pricing roughly a ±8.0% move by that expiry — a range of about $48.28–$56.64.

Put/call ratio (2026-09-18)
0.93
ATM implied volatility
76.6%
Total open interest
12,309
Expected move by 2026-09-18
±8.0% ($48.28–$56.64)

Analyst Rating Changes

Are analysts turning bullish or bearish on CRSP?

Citizens most recently reiterated its rating on CRISPR Therapeutics AG to Market Outperform on Aug 31, 2026 with a price target of $80. Over the last 90 days, coverage has run 0 upgrades against 0 downgrades, a net mixed lean.

Latest action
CitizensMarket Outperform
90-day upgrades
0
90-day downgrades
0
Net rating momentum
0
DateFirmActionRatingPrice target
Aug 31, 2026CitizensReiteratedMarket Outperform$80
Aug 31, 2026NeedhamReiteratedBuy$82
Aug 25, 2026CitizensReiteratedMarket Outperform$80
Aug 4, 2026CitigroupMaintainedBuy$82 → $88
Jul 8, 2026HC Wainwright & Co.ReiteratedBuy$80
Jul 6, 2026CitizensReiteratedMarket Outperform$80
May 13, 2026BernsteinMaintainedMarket Perform$50 → $56
May 6, 2026CitigroupMaintainedBuy$80 → $82
Mar 17, 2026Piper SandlerReiteratedOverweight$105 → $110
Feb 17, 2026Chardan CapitalMaintainedBuy$74 → $76
Feb 13, 2026TD CowenMaintainedHold$40 → $45
Feb 13, 2026Evercore ISI GroupMaintainedOutperform$62 → $74

CRSP Competitive Positioning

CRISPR Therapeutics AG (CRSP) is tracked alongside these names in Biotechnology on DailyIQ — ranked by market cap, with today's move alongside.

Held by These ETFs

CRSP is a top holding in these ETFs tracked on DailyIQ — bar length shows portfolio weight.