CRSP·CRISPR Therapeutics AG

Realized volatility (21d)

59.7% 52nd pct

Below its peak

-76.4%

vs 200-day average

-5.6%

Up days (1y)

44%

CRISPR Therapeutics AG is currently running 59.7% annualised volatility over the last 21 sessions. Measured against CRSP's own 10 years of daily returns rather than a market-wide average, that is the 52nd percentile — close to its own typical level, against a typical reading of 59.1%. The distinction matters because a number that looks calm for one stock is turbulent for another, and the absolute figure on its own tells you neither.

CRSP is trading -76.4% below its running peak. Across 9 full years on file, its median worst-drawdown-in-a-year was -43.6%, and the deepest was -67.2% in 2021. The current drawdown is already deeper than this stock's typical annual low point, which puts it in the part of its range where past recoveries began — and where past declines also continued.

Price sits -5.6% from its 200-day moving average. Against every other day in its history, that gap ranks at the 41st percentile — close to the gap it normally carries. Over the past year CRSP closed higher on 44% of sessions, and it is currently 1 session into a rising streak.

On October specifically: over 10 years of records, CRSP finished the month higher 5 of 10 times, with a median return of -0.2% and an average of -2.1%. Its strongest month historically has been November at +15.1% on average, its weakest March at -9.9%. Seasonality is a weak signal on its own — a decade is a small sample and regimes change — but it is a real distribution rather than a rule of thumb.

Overnight risk is measurable too: CRSP has opened more than 2% away from the prior close in 362 of 2,509 sessions (14.4% of the time), with the largest gaps running +13.9% and -10.1%. For anyone holding through an event, that rate is a better guide to overnight exposure than the intraday range.

All figures computed from 2,510 daily closes between 2016-10-19 and 2026-10-14, split-adjusted, recomputed daily. Percentiles are against CRSP's own 10-year history, not a peer group or index.