DailyIQ
Last updated 1 hour ago

CRSP·CRISPR Therapeutics AG

$.
+. (+.%)
High
$51.31
Open
$50.64
Market Cap
4.86B
52W High
$78.48
Low
$50.52
P. Close
$50.36
P/E
-
52W Low
$35.38
Fwd P/E
-
Mean Target
-
Technical Score (1D)
32
SELL
News Sentiment
60
BULLISH
CRISPR Therapeutics' gene-editing therapy, Casgevy, has received approval for sickle cell disease and beta-thalassemia, marking a significant clinical advancement. This development positions the company within the growing gene-editing biotechnology sector. Investors are closely watching CRISPR Therapeutics as it is being evaluated against competitors like Beam Therapeutics, with upcoming catalysts expected to influence performance.
Earnings Summary
CRISPR Therapeutics AG is a biotechnology company focused on developing novel gene-editing therapies using its proprietary CRISPR/Cas9 platform. The company aims to create potentially curative treatments for serious diseases, with a primary focus on hemoglobinopathies and a pipeline targeting oncology, autoimmune diseases, and other conditions. CRISPR Therapeutics operates within the dynamic and highly innovative biotechnology sector, characterized by significant research and development investment and regulatory scrutiny. In its most recent reported quarters, CRSP demonstrated a trend of improving actual earnings per share (EPS) compared to analyst estimates, with EPS moving from a loss of -1.58 in Q1 2025 to -1.17 in Q3 2025, exceeding expectations in both periods. Revenue, while still nascent, saw a significant increase from $0.87 million in Q2 2025 to $0.89 million in Q3 2025, indicating early commercial traction. Historically, the company has shown a pattern of consistent revenue growth, though EPS has largely remained in negative territory as is common for development-stage biotechs. For instance, comparing Q4 2024's actual EPS of -0.44 to Q1 2025's -1.58 shows a widening loss, but Q2 2025 and Q3 2025 saw sequential improvements in EPS relative to estimates. Recent news highlights CRISPR Therapeutics entering a new phase focused on pipeline development following the launch of CASGEVY, with expectations for data from six pipeline assets within 12-18 months. The CEO has indicated 2026 as a critical year for significant readouts from early-stage programs. Investors will be watching for upcoming pipeline data readouts and clinical trial updates, as well as the continued commercial momentum and reimbursement timelines for CASGEVY, to gauge future growth drivers and the company's ability to balance pipeline advancement with commercialization efforts.

EPS

EstBeatMiss
$-1.75$-1.38$-1.01$-0.64$-0.27Q4'24Q1'25Q2'25Q3'25Q4'25
QtrEstActual+/−
Q4'25$-1.18 - -
Q3'25$-1.29$-1.17+9.2%
Q2'25$-1.40$-1.29+7.8%
Q1'25$-1.28$-1.58-23.8%
Q4'24$-1.19$-0.44+62.9%

Revenue

EstBeatMiss
$-4M$7M$18M$30M$41MQ4'24Q1'25Q2'25Q3'25Q4'25
QtrEstActual+/−
Q4'25$6M - -
Q3'25 - $889,000 -
Q2'25 - $892,000 -
Q1'25 - $865,000 -
Q4'24 - $36M -

Market Data

CRSP Stock Snapshot

CRSP is currently trading at $50.76, giving CRISPR Therapeutics AG a market cap of 4.86B. Today's range spans $50.52–$51.31, with shares opening at $50.64 and moving up $0.40 (0.8%) from the prior close. DailyIQ's technical score sits at 32/100 (SELL) with a news sentiment reading of 60/100.

Over the past year CRSP has traded between $35.38 and $78.48 - the current price is +43.5% off the 52-week low and -35.3% from the high.

Mean-reversion potential exists for CRSP - but it needs a catalyst. 32/100 (SELL), bullish sentiment (60/100), price $50.76 (in the lower half of its 52-week range in $35.38–$78.48). At 4.86B in Healthcare market cap, small-cap stocks in bearish phases don't typically recover on technicals alone - they need a news event, earnings surprise, or sector catalyst to shift the momentum. Without one, the SELL setup tends to persist longer than fundamental analysis would suggest.

Small-cap Healthcare names with SELL technicals (32/100) and bullish sentiment (60/100) like CRSP tend to experience sentiment-driven re-ratings more sharply in both directions. At $50.76 (in the lower half of its 52-week range in $35.38–$78.48), the current setup suggests a stock that needs a material positive catalyst — not incremental improvement — to reverse the technical and sentiment readings that now define the 4.86B market cap trajectory.

Recent News Coverage

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