13F-HRCIK 0001306923
Last filed Aug 19, 2026Palo Alto Investors LP·13F Holdings
$165.9M-11.4% vs prior quarter
- Positions
- 11
- Top-10 weight
- 99%
- Largest
- INSM · 27%
- Quarter ending
- Jun 30, 2026
- Added
- 0
- Trimmed
- 5
- Sold out
- 0
- Last filed
- Aug 19, 2026
Portfolio
What does Palo Alto Investors LP own?
Palo Alto Investors LP reported 11 long equity positions worth $165.9M for the quarter ending Jun 30, 2026. The largest is INSM at 27% of reported value. The ten largest positions make up 99% of the portfolio. Against the prior quarter it added to 0 positions, trimmed 5 and sold out of 0. The latest 13F was filed Aug 19, 2026.
Largest positionsValue · weight
- INSMInsmed Incorporated$44.1M27% of portfolio
- BMRNBioMarin Pharmaceutical Inc.$39.1M24% of portfolio
- UTHRUnited Therapeutics Corporation$33.9M20% of portfolio
- BIIBBiogen Inc.$30.3M18% of portfolio
- ALGNAlign Technology, Inc.$5.3M3.2% of portfolio
- NBIXNeurocrine Biosciences Inc.$3.1M1.8% of portfolio
- EWEdwards Lifesciences Corporation$3.0M1.8% of portfolio
- CYTKCytokinetics Incorporated$2.7M1.7% of portfolio
- BNTXBioNTech SE$1.8M1.1% of portfolio
- HUMHumana Inc.$1.6M1.0% of portfolio
Sector tilt
Which sectors does Palo Alto Investors LP lean on?
Healthcare (53%) and Health technology (47%) are the two largest sectors by reported value.
By share of reported value, across 11 classified tickers.
Quarter changes
What did Palo Alto Investors LP buy and sell last quarter?
Reported value
How has Palo Alto Investors LP's 13F value moved?
Reported value went from $395.8M to $165.9M over 10 quarters. It moves with prices and with buying and selling, so it is not a fund return.
$395.8MMar 2024
$405.1MJun 2024
$383.5MSep 2024
$312.7MDec 2024
$242.1MMar 2025
$226.7MJun 2025
$190.7MSep 2025
$205.0MDec 2025
$187.3MMar 2026
$165.9MJun 2026
Latest 13F
What Palo Alto Investors LP changed in its latest 13F
| Company | Change | Shares vs prior | Est. value | Filed |
|---|---|---|---|---|
| Align Technology, Inc. ALGN | -24% | $1.7M | Aug 19, 2026 | |
| BioMarin Pharmaceutical Inc. BMRN | -0.4% | $138K | Aug 19, 2026 | |
| Insmed Incorporated INSM | -0.3% | $137K | Aug 19, 2026 | |
| United Therapeutics Corporation UTHR | -0.4% | $120K | Aug 19, 2026 | |
| Biogen Inc. BIIB | -0.3% | $95K | Aug 19, 2026 |