ARWR·Arrowhead Pharmaceuticals Inc.

Realized volatility (21d)

63.2% 53rd pct

Below its peak

-31.0%

vs 200-day average

-13.9%

Up days (1y)

48%

Arrowhead Pharmaceuticals Inc. is currently running 63.2% annualised volatility over the last 21 sessions. Measured against ARWR's own 13 years of daily returns rather than a market-wide average, that is the 53rd percentile — close to its own typical level, against a typical reading of 61.2%. The distinction matters because a number that looks calm for one stock is turbulent for another, and the absolute figure on its own tells you neither.

ARWR is trading -31.0% below its running peak. Across 12 full years on file, its median worst-drawdown-in-a-year was -51.0%, and the deepest was -84.7% in 2016. The current pullback is therefore shallower than what this stock gives back in a typical year, which is context worth having before treating it as a dislocation.

Price sits -13.9% from its 200-day moving average. Against every other day in its history, that gap ranks at the 33rd percentile — close to the gap it normally carries. Over the past year ARWR closed higher on 48% of sessions, and it is currently 4 sessions into a falling streak.

On October specifically: over 13 years of records, ARWR finished the month higher 7 of 13 times, with a median return of +0.3% and an average of -1.7%. Its strongest month historically has been December at +10.3% on average, its weakest March at -10.6%. Seasonality is a weak signal on its own — a decade is a small sample and regimes change — but it is a real distribution rather than a rule of thumb.

Overnight risk is measurable too: ARWR has opened more than 2% away from the prior close in 529 of 3,267 sessions (16.2% of the time), with the largest gaps running +21.1% and -15.5%. For anyone holding through an event, that rate is a better guide to overnight exposure than the intraday range.

All figures computed from 3,268 daily closes between 2013-10-07 and 2026-10-05, split-adjusted, recomputed daily. Percentiles are against ARWR's own 13-year history, not a peer group or index.