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DailyIQ
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MAZE·Maze Therapeutics, Inc.

$34.50
+1.97 (+6.06%)
High
$35.00
Open
$32.72
Market Cap
1.85B
52W High
$60.00
Low
$29.00
P. Close
$34.50
P/E
-
52W Low
$21.95
Fwd P/E
-10.21
DailyIQ Est.
$70.40
Inst. Own.
18.0%
Short Interest
13.91%
Days to Cover
10.1
NewEarnings release, scored · filed Aug 11, 2026tone +7.3 vs prior release · 31 lines scoredSee the breakdown
Technical Score (1D)
20
BEARISH
News Sentiment
74
BULLISH
On Nov 4, analysts reported a mean short‑term price target of $62.54 for Maze Therapeutics, implying a potential upside of about 94 percent from its recent closing price of $32.25. The target range extended from $46.00 to $110.00, indicating significant optimism among the 13 analysts surveyed. The stock had already risen 22 percent over the past month, suggesting that some of the upside may already have been priced in. The wide spread in estimates reflected uncertainty about the company’s near‑term prospects. No other developments were reported for Maze Therapeutics on that date.
LOW TARGET
$46 +33.3%
2 analysts
MEAN TARGET
$63 +81.3%
3 analysts
HIGH TARGET
$110 +218.8%
17 analysts
PRICE RANGE
$46.00 - $110.00
SB / B / H / S / SS
8/11/1/1/1
DAILYIQ EST.
$70.40 (+104.1%)
Bought (1Y)
0 shares
$0
Sold (1Y)
269,493 shares
$7.4M
Coloma Jason VChief Executive Officer
Sell5,345 shares2026-11-02
Coloma Jason VChief Executive Officer
Sell26,563 shares2026-11-02
Coloma Jason VChief Executive Officer
Sell336 shares2026-11-02
Coloma Jason VChief Executive Officer
Sell2,257 shares2026-11-02
Dandekar AtulCSBO
Option Exercise857 shares2026-10-29
38/ 100
Bearish
Overall: Bearish
✕Negative net margin
✕Negative operating cash flow
✓Manageable liabilities relative to assets
Net Margin
-78.3%
Current Ratio
15.50x
Return on Equity
-36.9%

EPS

EstBeatMiss
$-0.81$-0.77$-0.73$-0.68$-0.64Q3'25Q3'26
QtrEstActual+/−
Q3'26$-0.79 - -
Q3'25$-0.69$-0.66+4.7%

Revenue

EstBeatMiss
$-0.15$-0.075$0$0.075$0.15Q3'25Q3'26
QtrEstActual+/−
Q3'26$0 - -
Q3'25 - $0 -

Market Data

MAZE Stock Snapshot

BEARISH20/100
$34.50+$1.97 (6.1%)
Market cap
1.85B
Day range
$29.00 – $35.00
News sentiment
74/100 · Bullish
Analyst target
$62.54 (+81.3%)
Consensus
Buy · 22 analysts
52-week range+57.2% off low · -42.5% from high
$21.95$60.00
Price $34.50 DailyIQ Est. $70.40

MAZE is on the weaker side of its setup, with little confirmation for a reversal yet. Company-specific news dominates here; sector-level flows matter less than for larger names.

Behaviour On Record

What MAZE's own history says about today's numbers

Realized volatility (21d)
56.9% 39th pct

Maze Therapeutics, Inc. is currently running 56.9% annualised volatility over the last 21 sessions. Measured against MAZE's own 2 years of daily returns rather than a market-wide average, that is the 39th percentile — on the quiet side for this stock, against a typical reading of 63.4%.

Overnight risk is measurable too: MAZE has opened more than 2% away from the prior close in 103 of 442 sessions (23.3% of the time), with the largest gaps running +31.2% and -22.8%.

All figures computed from 443 daily closes between 2025-01-31 and 2026-11-04, split-adjusted, recomputed daily. Percentiles are against MAZE's own 2-year history, not a peer group or index.

Sector Rotation

Is money rotating into or out of MAZE's sector?

Maze Therapeutics, Inc. sits in the Health Care sector, currently ranked 1st of 12 GICS sectors by relative-strength rotation score (weakening). Within its narrower Biotechnology industry group, MAZE ranks 7th of 15 tracked industries, weakening.

Sector rank
#1 of 12
Sector state
Weakening
Sector rotation score
100
Industry rank
#7 of 15

Options Market

What is the options market pricing for MAZE?

CallsPuts

For Maze Therapeutics, Inc.'s nearest expiry (2026-11-20, 14 days out), open interest is call-heavy, a bullish tilt (put/call ratio of 0.79), with at-the-money implied volatility around 72.2%. The options market is pricing roughly a ±14.1% move by that expiry — a range of about $29.37–$39.05.

Put/call ratio (2026-11-20)
0.79
ATM implied volatility
72.2%
Total open interest
1,508
Expected move by 2026-11-20
±14.1% ($29.37–$39.05)

Analyst Consensus Estimates

What do analysts expect MAZE to earn?

Analysts expect Maze Therapeutics, Inc. to earn -$2.73 per share in the fiscal year ending Dec 2026 and -$2.98 in the fiscal year ending Dec 2029, from 3 estimates. These are analyst forecasts, not company guidance, and later years rest on fewer analysts.

Quarter endingEPS estimateEPS rangeEPS analystsRevenue estimateRevenue analysts
Sep 2026-$0.75-$0.87 to -$0.5610$0M12
Dec 2026-$0.79-$0.94 to -$0.5710$0M12
Mar 2027-$0.72-$0.84 to -$0.654--
Jun 2027-$0.72-$0.87 to -$0.614--
Sep 2027-$0.74-$0.90 to -$0.634--
Fiscal year endingEPS estimateEPS rangeEPS analystsRevenue estimateRevenue analysts
Dec 2026-$2.73-$3.06 to -$2.0710$20M13
Dec 2027-$3.19-$4.28 to -$2.3110$7M13
Dec 2028-$3.06-$3.65 to -$2.234--
Dec 2029-$2.98-$3.92 to -$2.053--

Analyst Rating Changes

Are analysts turning bullish or bearish on MAZE?

Canaccord Genuity most recently initiated coverage on Maze Therapeutics, Inc. to Buy on Oct 19, 2026 with a price target of $75. Over the last 90 days, coverage has run 0 upgrades against 0 downgrades, a net mixed lean.

Latest action
Canaccord Genuity: Buy
90-day upgrades
0
90-day downgrades
0
Net rating momentum
0
DateFirmActionRatingPrice target
Oct 19, 2026Canaccord GenuityInitiatedBuy$75
Sep 24, 2026HC Wainwright & Co.ReiteratedBuy$110
Sep 23, 2026CitigroupInitiatedBuy$50
Sep 23, 2026WedbushReiteratedOutperform$48
Sep 22, 2026BTIGReiteratedBuy$46
Aug 12, 2026BTIGReiteratedBuy$46
Apr 14, 2026Truist SecuritiesMaintainedBuy$68 → $64
Mar 31, 2026JP MorganMaintainedOverweight$52 → $58
Mar 25, 2026BTIGReiteratedBuy$46
Mar 25, 2026HC Wainwright & Co.MaintainedBuy$60 → $110
Mar 18, 2026Truist SecuritiesInitiatedBuy$68
Mar 16, 2026WedbushMaintainedOutperform$43 → $58

Corporate Stakes

Which companies own a stake in MAZE?

2.57%held by GOOGL

Alphabet Inc. reports a stake in Maze Therapeutics, Inc. on SEC Form 13F: 1.4M shares, about 2.57% of the company, worth $41.4M at the end of Q2 2026. At today's price that stake is worth $47.9M, about 0.00% of GOOGL's own market value.

Holder
GOOGL
Shares held
1.4M
Stake
2.57%
Value
$41.4M
HolderLast quarterShares% of MAZEValue at filingValue nowChange
Alphabet Inc. GOOGLUnchanged1.4M2.57%$41.4M$47.9M+15.6%

Form 13F lists US-listed shares held at quarter-end and is filed up to 45 days later. Stakes in private companies are not on it. Value now and Change put those same shares, adjusted for any stock split, at today's price against their reported quarter-end value, so they do not reflect buying or selling since.

Earnings Release, Scored

What did Maze Therapeutics, Inc.'s latest earnings release say?

Filed Aug 11, 2026 · SEC Form 8-K, Exhibit 99

Tone61.9/ 100+7.3 vs prior release
Hedging words0.13per 100 words+0.01 vs prior release
Tone, last 2 releasesScale 49–69

Most important lines

  1. 1

    Net Loss: Net loss for the three and six months ended June 30, 2026 was $44.7 million, or $0.76 per share, and $68.9 million, or $1.22 per share, respectively, compared to net loss of $33.7 million, or $0.77 per share, and $66.5 million, or $1.83 per share, for the same periods in 2025.

    New this quarterNegative tone
  2. 2

    We are also advancing MZE782 toward a Phase 2 trial in CKD, which we expect to initiate in the first half of next year.

    New this quarter
  3. 3

    The increase primarily reflects higher expenses related to the progression of our clinical development of the MZE829 program and higher personnel-related costs, including non-cash stock-based compensation expense.

ETF holders

ETFs holding MAZE

News & sentiment

What is the news saying about MAZE?

MAZE rose 30.5% over the month to Nov 6. News tone held between 42 and 99 from Oct 6 to Nov 3, then jumped to 80 on Nov 4.

Daily close and news tone, Oct 6 to Nov 6
$25$30$35Oct 6: tone 42Oct 7Oct 8Oct 9Oct 12Oct 13: tone 99Oct 14Oct 15Oct 16Oct 19: tone 79Oct 20Oct 21Oct 22Oct 23Oct 26Oct 27Oct 28Oct 29Oct 30Nov 2Nov 3: tone 44Nov 4: tone 80Nov 5Nov 6Oct 6News toneNov 6123
  1. Oct 19 +7.7%same day: How Much Upside is Left in Maze Therapeutics, Inc. (MAZE)? Wall Street Analysts Think 123.39%
  2. Oct 20 +10.4%
  3. Nov 3 +6.2%same day: Maze Therapeutics to Participate in Upcoming Investor Conferences

Technical analysis

How strong is MAZE's momentum right now?

On the daily chart MAZE ranks at the 20th percentile for momentum against 1,060 stocks and ETFs, a bearish reading.

Momentum rank by timeframe0 = weakest, 100 = strongest
See what drives the rankThe inputs behind each timeframe's momentum rank, plus RSI, stochastics, Bollinger Bands and moving averages. Free with an account.

Institutional ownership

Are big funds buying or selling MAZE?

43 of the 60 tracked managers added to MAZE in their latest 13F and 13 trimmed. Together they own 15.5% of the company, worth $248.4M. Vanguard Capital Management and State Street alone hold 5.1%.

43adding13trimming4unchanged
Largest holders by stake, latest 13FBar = share of MAZE
  1. $53.1M positionAdded 23.9% last quarter
  2. $29.8M positionAdded 56.7% last quarter
  3. $28.5M positionAdded 50.1% last quarter
  4. $22.0M positionAdded 13.2% last quarter
  5. $11.7M positionAdded 101.0% last quarter
  6. $11.5M positionAdded 69.6% last quarter
  7. $7.5M positionUnchanged last quarter
  8. $8.1M positionAdded 261.9K shares last quarter
  9. $7.8M positionAdded 39.8% last quarter
  10. $6.8M positionAdded 111.6% last quarter
Full holdings history

Discover more

How has MAZE done against its peers?

Over the six months to Nov 6, MAZE returned +30.4%. Of the 15 related stocks and ETFs, 6 did better, led by MRNA at +424.4%.

Change since May 6, through Nov 6
−200%0%+200%+400%+600%May 6JunJulAugSepOctNov 6MRNA +424.4%MAZE +30.4%INSM −20.3%